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Description
Gibco KnockOut Serum Replacement (KnockOut SR) is a more defined, foetal bovine serum (FBS)-free medium supplement developed to support the growth and maintenance of pluripotent stem cells (PSCs) cultured on fibroblast feeder cells. Designed as an alternative to FBS in established cell culture protocols, it offers improved consistency and reduced lot-to-lot variability.
With an established history of use in stem cell research, KnockOut SR supports a range of applications, including embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) culture, reprogramming, differentiation and cryopreservation.
Key Features
- FBS-free formulation designed as an alternative to foetal bovine serum.
- Supports the growth and maintenance of feeder-dependent pluripotent stem cells.
- Suitable for embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) culture.
- More defined formulation than conventional FBS, helping reduce variability.
- Each lot tested for its ability to support pluripotent stem cell culture.
- Helps minimise spontaneous differentiation and supports more compact colony morphology compared to FBS.
- Suitable for stem cell reprogramming and embryoid body (EB) formation.
- Supports in vitro differentiation, cryopreservation and ESC derivation.
- Established track record, with more than 2,000 scientific publications citing its use.
- Provides supporting documentation for regulatory review when transitioning from research towards clinical applications.
Additional Benefits
- More consistent pricing and supply compared to conventional FBS.
- Helps simplify reagent qualification when progressing from research applications towards clinical use.
- Provides an established alternative to serum-based supplementation in existing stem cell culture protocols.
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